| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 23rd, 2008 | 22 | Yes |
Popular Name: 6-[(3-ethyl-4-methyl-phenyl)amino]-3-(2-methoxyethyl)-1H-pyrimidine-2,4-dione 6-[(3-ethyl-4-methyl-phenyl)amin…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.78 | 6.97 | -9.4 | 2 | 6 | 0 | 76 | 303.362 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| RPC10-1-E | DNA-directed RNA Polymerases III 12.5 KDa Polypeptide (cluster #1 Of 1), Eukaryotic | Eukaryotes | 580 | 0.40 | Binding ≤ 10μM |
| RPC4-1-E | DNA-directed RNA Polymerase III 47 KDa Polypeptide (cluster #1 Of 1), Eukaryotic | Eukaryotes | 580 | 0.40 | Binding ≤ 10μM |
| RPC6-1-E | DNA-directed RNA Polymerase III 39 KDa Polypeptide (cluster #1 Of 1), Eukaryotic | Eukaryotes | 580 | 0.40 | Binding ≤ 10μM |
| DPO3-1-B | DNA Polymerase III (cluster #1 Of 1), Bacterial | Bacteria | 127 | 0.44 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPO3_BACSU | P13267 | DNA Polymerase III, Bacsu | 127 | 0.44 | Binding ≤ 1μM |
| RPC6_HUMAN | Q9H1D9 | DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human | 580 | 0.40 | Binding ≤ 1μM |
| RPC4_HUMAN | P05423 | DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human | 580 | 0.40 | Binding ≤ 1μM |
| RPC10_HUMAN | Q9Y2Y1 | DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human | 580 | 0.40 | Binding ≤ 1μM |
| DPO3_BACSU | P13267 | DNA Polymerase III, Bacsu | 127 | 0.44 | Binding ≤ 10μM |
| RPC6_HUMAN | Q9H1D9 | DNA-directed RNA Polymerase III 39 KDa Polypeptide, Human | 580 | 0.40 | Binding ≤ 10μM |
| RPC4_HUMAN | P05423 | DNA-directed RNA Polymerase III 47 KDa Polypeptide, Human | 580 | 0.40 | Binding ≤ 10μM |
| RPC10_HUMAN | Q9Y2Y1 | DNA-directed RNA Polymerases III 12.5 KDa Polypeptide, Human | 580 | 0.40 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Cytosolic sensors of pathogen-associated DNA | |
| RNA Polymerase III Abortive And Retractive Initiation | |
| RNA Polymerase III Chain Elongation | |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | |
| RNA Polymerase III Transcription Termination |
