| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 23rd, 2008 | 29 | Yes |
Popular Name: 3-[2-isobutoxy-5-(4-isobutoxybenzoyl)phenyl]propanoic 3-[2-isobutoxy-5-(4-isobutoxyben…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.62 | 12.49 | -55.86 | 0 | 5 | -1 | 76 | 397.491 | 11 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FOS-2-E | Proto-oncogene Protein C-fos (cluster #2 Of 2), Eukaryotic | Eukaryotes | 5000 | 0.26 | Binding ≤ 10μM |
| JUN-1-E | Proto-oncogene C-JUN (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5000 | 0.26 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| JUN_HUMAN | P05412 | Proto-oncogene C-JUN, Human | 5000 | 0.26 | Binding ≤ 10μM |
| FOS_HUMAN | P01100 | Proto-oncogene Protein C-fos, Human | 5000 | 0.26 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of the AP-1 family of transcription factors | |
| FCERI mediated MAPK activation | |
| Oxidative Stress Induced Senescence | |
| Pre-NOTCH Transcription and Translation | |
| Senescence-Associated Secretory Phenotype (SASP) |
