| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 23rd, 2008 | 28 | No |
Popular Name: (2R,4R)-N-(3-benzoylphenyl)-2-(3-pyridyl)thiazolidine-4-carboxamide (2R,4R)-N-(3-benzoylphenyl)-2-(3…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.04 | 8.04 | -21.45 | 2 | 5 | 0 | 71 | 389.48 | 5 | ↓ |
| Lo Low (pH 4.5-6) | 3.04 | 9.12 | -116.38 | 4 | 5 | 2 | 77 | 391.496 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PTAFR-2-E | Platelet Activating Factor Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 5 | 0.42 | Binding ≤ 10μM |
| PTAFR-1-E | Platelet Activating Factor Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 8 | 0.40 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PTAFR_HUMAN | P25105 | Platelet Activating Factor Receptor, Human | 5 | 0.42 | Binding ≤ 1μM |
| PTAFR_HUMAN | P25105 | Platelet Activating Factor Receptor, Human | 5 | 0.42 | Binding ≤ 10μM |
| PTAFR_HUMAN | P25105 | Platelet Activating Factor Receptor, Human | 7.7 | 0.41 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | |
| G alpha (q) signalling events | |
| Interferon gamma signaling |
