| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 23rd, 2008 | 16 | Yes |
Popular Name: DNC004091 DNC004091
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.60 | 6.52 | -8.36 | 0 | 2 | 0 | 26 | 206.248 | 1 | ↓ |
| Lo Low (pH 4.5-6) | 2.60 | 6.8 | -34.72 | 1 | 2 | 1 | 27 | 207.256 | 1 | ↓ |
| Lo Low (pH 4.5-6) | 2.60 | 6.8 | -40.27 | 1 | 2 | 1 | 27 | 207.256 | 1 | ↓ |
| Lo Low (pH 4.5-6) | 2.60 | 7.08 | -88.01 | 2 | 2 | 2 | 28 | 208.264 | 1 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PGFRA-1-E | Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1500 | 0.51 | Binding ≤ 10μM |
| PGFRB-1-E | Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1500 | 0.51 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PGFRA_HUMAN | P16234 | Platelet-derived Growth Factor Receptor Alpha, Human | 1500 | 0.51 | Binding ≤ 10μM |
| PGFRB_HUMAN | P09619 | Platelet-derived Growth Factor Receptor Beta, Human | 1500 | 0.51 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Constitutive PI3K/AKT Signaling in Cancer | |
| Downstream signal transduction | |
| PIP3 activates AKT signaling | |
| Signaling by PDGF |
