In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
June 24th, 2008 | 36 | Yes |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 6.25 | 15.06 | -57.49 | 0 | 7 | -1 | 88 | 495.632 | 9 | ↓ |
Lo Low (pH 4.5-6) | 6.25 | 15.09 | -17.79 | 1 | 7 | 0 | 89 | 496.64 | 9 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
AGTRA-1-E | Angiotensin II Type 1a (AT-1a) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1 | 0.35 | Binding ≤ 10μM |
AGTRB-1-E | Angiotensin II Type 1b (AT-1b) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1 | 0.35 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
AGTRA_RAT | P25095 | Angiotensin II Type 1a (AT-1a) Receptor, Rat | 1.27 | 0.35 | Binding ≤ 1μM |
AGTRB_RAT | P29089 | Angiotensin II Type 1b (AT-1b) Receptor, Rat | 1.27 | 0.35 | Binding ≤ 1μM |
AGTRA_RAT | P25095 | Angiotensin II Type 1a (AT-1a) Receptor, Rat | 1.27 | 0.35 | Binding ≤ 10μM |
AGTRB_RAT | P29089 | Angiotensin II Type 1b (AT-1b) Receptor, Rat | 1.27 | 0.35 | Binding ≤ 10μM |
Description | Species |
---|---|
G alpha (q) signalling events | |
Peptide ligand-binding receptors |