Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.27	10.78	-11.64	1	5	0	68	355.397	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.27	11.08	-37.53	2	5	1	69	356.405	5	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	4.27	10.97	-42.16	2	5	1	69	356.405	5	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	4.27	11.37	-98.35	3	5	2	70	357.413	5	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
RAF1-1-E	Serine/threonine-protein Kinase RAF (cluster #1 Of 1), Eukaryotic	Eukaryotes	320	0.34	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
RAF1_HUMAN	P04049	Serine/threonine-protein Kinase RAF, Human	320	0.34	Binding ≤ 1μM
RAF1_HUMAN	P04049	Serine/threonine-protein Kinase RAF, Human	320	0.34	Binding ≤ 10μM

Description	Species
CREB phosphorylation through the activation of Ras	Homo sapiens (RAF1_HUMAN)
GP1b-IX-V activation signalling	Homo sapiens (RAF1_HUMAN)
MEK activation	Homo sapiens (RAF1_HUMAN)
RAF activation	Homo sapiens (RAF1_HUMAN)
RAF phosphorylates MEK	Homo sapiens (RAF1_HUMAN)
Rap1 signalling	Homo sapiens (RAF1_HUMAN)
Stimuli-sensing channels	Homo sapiens (RAF1_HUMAN)