| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 26th, 2008 | 25 | Yes |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.28 | 13.06 | -11.91 | 1 | 5 | 0 | 60 | 328.375 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CCND1-1-E | G1/S-specific Cyclin D1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 940 | 0.34 | Binding ≤ 10μM |
| CCND2-1-E | G1/S-specific Cyclin D2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 940 | 0.34 | Binding ≤ 10μM |
| CCND3-1-E | G1/S-specific Cyclin D3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 940 | 0.34 | Binding ≤ 10μM |
| CDK4-2-E | Cyclin-dependent Kinase 4 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 940 | 0.34 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CDK4_HUMAN | P11802 | Cyclin-dependent Kinase 4, Human | 940 | 0.34 | Binding ≤ 1μM |
| CCND1_HUMAN | P24385 | G1/S-specific Cyclin D1, Human | 940 | 0.34 | Binding ≤ 1μM |
| CCND2_HUMAN | P30279 | G1/S-specific Cyclin D2, Human | 940 | 0.34 | Binding ≤ 1μM |
| CCND3_HUMAN | P30281 | G1/S-specific Cyclin D3, Human | 940 | 0.34 | Binding ≤ 1μM |
| CDK4_HUMAN | P11802 | Cyclin-dependent Kinase 4, Human | 940 | 0.34 | Binding ≤ 10μM |
| CCND1_HUMAN | P24385 | G1/S-specific Cyclin D1, Human | 940 | 0.34 | Binding ≤ 10μM |
| CCND2_HUMAN | P30279 | G1/S-specific Cyclin D2, Human | 940 | 0.34 | Binding ≤ 10μM |
| CCND3_HUMAN | P30281 | G1/S-specific Cyclin D3, Human | 940 | 0.34 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Cyclin D associated events in G1 | |
| Meiotic recombination | |
| Oncogene Induced Senescence | |
| Oxidative Stress Induced Senescence | |
| Pre-NOTCH Transcription and Translation | |
| RMTs methylate histone arginines | |
| Senescence-Associated Secretory Phenotype (SASP) | |
| Transcriptional regulation of white adipocyte differentiation | |
| Ubiquitin-dependent degradation of Cyclin D1 |
