UCSF

ZINC13864596

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Substance Information

In ZINC since Heavy atoms Benign functionality
June 27th, 2008 31 No

Popular Name: 4-[(N'Z)-N'-[1-(3-chlorophenyl)-3-methyl-5-oxo-pyrazol-4-ylidene]hydrazino]-3-hydroxy-naphthalene-1- 4-[(N'Z)-N'-[1-(3-chlorophenyl)-…

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Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.58 2.13 -53.14 2 9 -1 140 457.875 4 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
TPOR-1-E Thrombopoietin Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 2000 0.26 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
TPOR_HUMAN P40238 Thrombopoietin Receptor, Human 2000 0.26 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Platelet Aggregation (Plug Formation)

Analogs ( Draw Identity 99% 90% 80% 70% )