| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 1st, 2008 | 23 | Yes |
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1092578-46-5 , 212143-23-2
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.45 | 7.48 | -24.61 | 1 | 7 | 0 | 89 | 312.377 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| JAK2-1-E | Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.53 | Binding ≤ 10μM |
| JAK3-2-E | Tyrosine-protein Kinase JAK3 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 190 | 0.41 | Binding ≤ 10μM |
| STK3-1-E | Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 450 | 0.39 | Binding ≤ 10μM |
| STK4-1-E | Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 250 | 0.40 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| STK4_HUMAN | Q13043 | Serine/threonine-protein Kinase MST1, Human | 250 | 0.40 | Binding ≤ 1μM |
| STK3_HUMAN | Q13188 | Serine/threonine-protein Kinase MST2, Human | 450 | 0.39 | Binding ≤ 1μM |
| JAK2_HUMAN | O60674 | Tyrosine-protein Kinase JAK2, Human | 1.8 | 0.53 | Binding ≤ 1μM |
| JAK3_HUMAN | P52333 | Tyrosine-protein Kinase JAK3, Human | 190 | 0.41 | Binding ≤ 1μM |
| STK4_HUMAN | Q13043 | Serine/threonine-protein Kinase MST1, Human | 250 | 0.40 | Binding ≤ 10μM |
| STK3_HUMAN | Q13188 | Serine/threonine-protein Kinase MST2, Human | 450 | 0.39 | Binding ≤ 10μM |
| JAK2_HUMAN | O60674 | Tyrosine-protein Kinase JAK2, Human | 1.8 | 0.53 | Binding ≤ 10μM |
| JAK3_HUMAN | P52333 | Tyrosine-protein Kinase JAK3, Human | 190 | 0.41 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Factors involved in megakaryocyte development and platelet production | |
| Growth hormone receptor signaling | |
| Interferon gamma signaling | |
| Interleukin receptor SHC signaling | |
| Interleukin-2 signaling | |
| Interleukin-3, 5 and GM-CSF signaling | |
| Interleukin-6 signaling | |
| Interleukin-7 signaling | |
| Prolactin receptor signaling | |
| Regulation of IFNG signaling | |
| RMTs methylate histone arginines | |
| Signaling by Hippo | |
| Signaling by Leptin | |
| Signaling by SCF-KIT |
