| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 18th, 2008 | 17 | No |
Popular Name: (3Z)-5-methyl-3-(1H-pyrrol-2-ylmethylene)indolin-2-one (3Z)-5-methyl-3-(1H-pyrrol-2-ylm…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.71 | 5.55 | -9.42 | 2 | 3 | 0 | 49 | 224.263 | 1 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PDPK1-1-E | 3-phosphoinositide Dependent Protein Kinase-1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2700 | 0.46 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PDPK1_HUMAN | O15530 | 3-phosphoinositide Dependent Protein Kinase-1, Human | 2700 | 0.46 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of PKB | |
| CD28 dependent PI3K/Akt signaling | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CTLA4 inhibitory signaling | |
| Downstream TCR signaling | |
| FCERI mediated NF-kB activation | |
| G beta:gamma signalling through PI3Kgamma | |
| GPVI-mediated activation cascade | |
| Integrin alphaIIb beta3 signaling | |
| PIP3 activates AKT signaling | |
| Role of LAT2/NTAL/LAB on calcium mobilization | |
| RSK activation | |
| VEGFR2 mediated cell proliferation | |
| VEGFR2 mediated vascular permeability |
