| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| December 31st, 2005 | 26 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.71 | -1.48 | -10.34 | 2 | 3 | 0 | 45 | 340.426 | 4 | ↓ |
| Lo Low (pH 4.5-6) | 4.71 | -1.34 | -32.85 | 3 | 3 | 1 | 46 | 341.434 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MDM2-1-E | P53-binding Protein Mdm-2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 120 | 0.37 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MDM2_HUMAN | Q00987 | P53-binding Protein Mdm-2, Human | 120 | 0.37 | Binding ≤ 1μM |
| MDM2_HUMAN | Q00987 | P53-binding Protein Mdm-2, Human | 120 | 0.37 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| AKT phosphorylates targets in the cytosol | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| Oncogene Induced Senescence | |
| Oxidative Stress Induced Senescence | |
| Stabilization of p53 | |
| Trafficking of AMPA receptors |
