| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 23rd, 2004 | 19 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.58 | 5.91 | -9.78 | 2 | 3 | 0 | 60 | 249.269 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FGFR1-1-E | Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4700 | 0.39 | Binding ≤ 10μM |
| FGFR2-1-E | Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4700 | 0.39 | Binding ≤ 10μM |
| FGFR3-1-E | Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4700 | 0.39 | Binding ≤ 10μM |
| FGFR4-1-E | Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4700 | 0.39 | Binding ≤ 10μM |
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3600 | 0.40 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FGFR1_HUMAN | P11362 | Fibroblast Growth Factor Receptor 1, Human | 4700 | 0.39 | Binding ≤ 10μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 4700 | 0.39 | Binding ≤ 10μM |
| FGFR3_HUMAN | P22607 | Fibroblast Growth Factor Receptor 3, Human | 4700 | 0.39 | Binding ≤ 10μM |
| FGFR4_HUMAN | P22455 | Fibroblast Growth Factor Receptor 4, Human | 4700 | 0.39 | Binding ≤ 10μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 3600 | 0.40 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activated point mutants of FGFR2 | |
| betaKlotho-mediated ligand binding | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| FGFR4 ligand binding and activation | |
| FRS2-mediated cascade | |
| Negative regulation of FGFR signaling | |
| Phospholipase C-mediated cascade | |
| PI-3K cascade | |
| PI3K Cascade | |
| PIP3 activates AKT signaling | |
| SHC-mediated cascade | |
| Signaling by activated point mutants of FGFR1 | |
| Signaling by activated point mutants of FGFR3 | |
| Signaling by ERBB2 | |
| Signaling by FGFR mutants | |
| Signaling by FGFR2 amplification mutants | |
| Signaling by FGFR3 mutants | |
| Signaling by FGFR4 mutants | |
| t(4;14) translocations of FGFR3 |
No pre-computed analogs available. Try a structural similarity search.