| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 9th, 2004 | 35 | No |
Popular Name: Sch-328725 Sch-328725
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.42 | 17.93 | -34.8 | 3 | 5 | 1 | 72 | 470.637 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PAR1-1-E | Proteinase Activated Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 65 | 0.29 | Binding ≤ 10μM |
| Z50587-1-O | Homo Sapiens (cluster #1 Of 9), Other | Other | 600 | 0.25 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PAR1_HUMAN | P25116 | Proteinase Activated Receptor 1, Human | 65 | 0.29 | Binding ≤ 1μM |
| PAR1_HUMAN | P25116 | Proteinase Activated Receptor 1, Human | 65 | 0.29 | Binding ≤ 10μM |
| Z50587 | Z50587 | Homo Sapiens | 265 | 0.26 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (q) signalling events | |
| Peptide ligand-binding receptors | |
| Thrombin signalling through proteinase activated receptors (PARs) |
