In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
October 9th, 2004 | 30 | Yes |
Popular Name: 4-fluorobutyl-(7-mesityl-2,5,6-trimethyl-pyrrolo[2,3-d]pyrimidin-4-yl)-propyl-amine 4-fluorobutyl-(7-mesityl-2,5,6-t…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 6.15 | 3.3 | -10.32 | 0 | 4 | 0 | 33 | 410.581 | 8 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
CRFR1-1-E | Corticotropin Releasing Factor Receptor 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 1 | 0.42 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
CRFR1_RAT | P35353 | Corticotropin Releasing Factor Receptor 1, Rat | 0.91 | 0.42 | Binding ≤ 1μM |
CRFR1_RAT | P35353 | Corticotropin Releasing Factor Receptor 1, Rat | 0.91 | 0.42 | Binding ≤ 10μM |
Description | Species |
---|---|
Class B/2 (Secretin family receptors) | |
G alpha (s) signalling events |