| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 9th, 2004 | 29 | Yes |
Popular Name: ethyl-(4-fluorobutyl)-(7-mesityl-2,5,6-trimethyl-pyrrolo[2,3-d]pyrimidin-4-yl)amine ethyl-(4-fluorobutyl)-(7-mesityl…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.65 | 3.37 | -10.21 | 0 | 4 | 0 | 33 | 396.554 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CRFR1-1-E | Corticotropin Releasing Factor Receptor 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 4 | 0.41 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CRFR1_RAT | P35353 | Corticotropin Releasing Factor Receptor 1, Rat | 3.5 | 0.41 | Binding ≤ 1μM |
| CRFR1_RAT | P35353 | Corticotropin Releasing Factor Receptor 1, Rat | 3.5 | 0.41 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Class B/2 (Secretin family receptors) | |
| G alpha (s) signalling events |
