UCSF

ZINC01910234

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Substance Information

In ZINC since Heavy atoms Benign functionality
October 9th, 2004 23 No

Popular Name: SL327 SL327

Find On: PubMed — Wikipedia — Google

CAS Numbers: 305350-87-2 , [305350-87-2]

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.06 6.95 -11.64 4 3 0 76 335.354 4 ↓
Lo Low (pH 4.5-6) 3.06 6.73 -38.57 5 3 1 77 336.362 4 ↓

Vendor Notes

Note Type Comments Provided By
Target MEK Selleck Chemicals
PUBCHEM_PATENT_ID WO2000056706A1 IBM Patent Data

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
JUN-1-E Proto-oncogene C-JUN (cluster #1 Of 2), Eukaryotic Eukaryotes 2030 0.35 Binding ≤ 10μM
MP2K2-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 220 0.41 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
MP2K2_HUMAN P36507 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 220 0.41 Binding ≤ 1μM
MP2K2_HUMAN P36507 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 220 0.41 Binding ≤ 10μM
JUN_HUMAN P05412 Proto-oncogene C-JUN, Human 2030 0.35 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Activation of the AP-1 family of transcription factors
ERK2 activation
FCERI mediated MAPK activation
MEK activation
Oxidative Stress Induced Senescence
Pre-NOTCH Transcription and Translation
RAF phosphorylates MEK
Senescence-Associated Secretory Phenotype (SASP)
Signal transduction by L1
Signaling by FGFR
Uptake and function of anthrax toxins

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.