UCSF

ZINC19796107

Substance Information

In ZINC since Heavy atoms Benign functionality
November 10th, 2008 29 No

Other Names:

"Uridine 5'-triphosphate trisodium salt hydrate, 95%"

({[(2R,3S,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid

5'-UTP; BRN 0071520; C9H15N2O15P3; EINECS 200-558-7; INS316; INS365 Ophthalmic Solution; LS-160841; UTP; Uridine 5'-(tetrahydrogen triphosphate); Uridine 5'-triphosphate; Uridine 5'-triphosphoric acid; Uridine triphosphate; Uridine, 5'-(tetrahydrogen trip

5'-UTP; BRN 0071520; URIDINE 5'-TRIPHOSPHATE; UTP; Uridine 5'-(tetrahydrogen triphosphate); Uridine 5'-triphosphoric acid; Uridine triphosphate; Uteplex; bmse000295

5'-UTP; H4utp; uridine 5'-triphosphoric acid

5'-UTP; Uridine 5'-triphosphate; Uridine mono(tetrahydrogen triphosphate); Uridine triphosphate; Uridine triphosphic acid; Uteplex; UTP

5'-UTP; UTP; Uridine 5'-triphosphate; Uridine mono(tetrahydrogen triphosphate); Uridine triphosphate; Uteplex

5'-UTP;Uridine 5'-triphosphate;Uridine mono(tetrahydrogen triphosphate);Uridine triphosphate;Uteplex;UTP

5'-UTP;UTP;Uridine 5'-triphosphate;Uridine mono(tetrahydrogen triphosphate);Uridine triphosphate;Uteplex

63-39-8; C00075; UTP; Uridine 5'-triphosphate; Uridine triphosphate

63-39-8; UTP; uridine-5'-triphosphate; uridine-triphosphate

CHEBI:13510; CHEBI:9850; CHEBI:27233

DNC001492

MFCD00044310

MFCD00058360

MFCD00150714

MFCD00274571

MFCD11101450

NA

QB-2953

SS-7954

Uridine 5'-triphosphate

Uridine 5'-triphosphate tris salt

Uridine 5'-Triphosphate Trisodium Salt Hydrate

Uridine 5'-triphosphate, trisodium salt, hydrate, 90%

Uridine triphosphate

uridine triphosphate trisodium

URIDINE-13C9, 15N2-5 TRIPHOSPHATE SODI U

URIDINE-13C9,15N2-5TRIPHOSPHATESODIU

Uridine-5'-triphosphate disodium salt

Uridine-5'-triphosphate trisodium salt

Uridine-5'-triphosphate trisodium salt dihydrate

Uridine5'-(tetrahydrogen triphosphate)

UTP

UTP (3-); UTP trianion

UTP(3-)

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -4.57 -4.59 -370.18 3 17 -4 276 480.108 8
Mid Mid (pH 6-8) -4.57 -5.75 -234.35 4 17 -3 273 481.116 8

Vendor Notes

Note Type Comments Provided By
Mp [°C] >140 Acros Organics
UniProt Database Links ACKA_SALTY; ACKA_THEMA; ACTH_THEAC; ACTH_THEVO; AGLF_HALVD; ARC_RHOER; CBACL_PSEUC; CDA_MYROD; CELA_GLUXY; COFE_METJA; DER_THEMA; DGK_BACSU; ENPP1_HUMAN; ENPP1_MOUSE; ENPP1_RAT; ENTP2_HUMAN; ENTP4_HUMAN; ENTP7_HUMAN; ENTP7_MOUSE; ENTP7_PONAB; ENTP7_XENTR ChEBI
Therapy psychostimulant SMDC MicroSource
Reactome Database Links REACT_1082; REACT_1094; REACT_1138; REACT_1160; REACT_1179; REACT_1374; REACT_1467; REACT_15538; REACT_1611; REACT_1638; REACT_1645; REACT_18287; REACT_18310; REACT_2030; REACT_2053; REACT_209; REACT_21273; REACT_21292; REACT_21305; REACT_21362; REACT_214 ChEBI
S phrase S24/25: Avoid contact with skin and eyes. Acros Organics
Patent Database Links US2007219224; WO2007089703 ChEBI

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
P2RY2-1-E Purinergic Receptor P2Y2 (cluster #1 Of 1), Eukaryotic Eukaryotes 60 0.35 Functional ≤ 10μM
P2RY2-1-E Purinergic Receptor P2Y2 (cluster #1 Of 1), Eukaryotic Eukaryotes 130 0.33 Functional ≤ 10μM
P2RY4-1-E Pyrimidinergic Receptor P2Y4 (cluster #1 Of 1), Eukaryotic Eukaryotes 90 0.34 Functional ≤ 10μM
P2RY4-1-E Pyrimidinergic Receptor P2Y4 (cluster #1 Of 1), Eukaryotic Eukaryotes 90 0.34 Functional ≤ 10μM
P2RY6-1-E Pyrimidinergic Receptor P2Y6 (cluster #1 Of 1), Eukaryotic Eukaryotes 6000 0.25 Functional ≤ 10μM
P2RY6-1-E Pyrimidinergic Receptor P2Y6 (cluster #1 Of 1), Eukaryotic Eukaryotes 6000 0.25 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
P2RY2_MOUSE P35383 P2Y Purinoceptor 2, Mouse 1260 0.28 Functional ≤ 10μM
P2RY2_RAT P41232 Purinergic Receptor P2Y2, Rat 130 0.33 Functional ≤ 10μM
P2RY2_HUMAN P41231 Purinergic Receptor P2Y2, Human 17.9 0.37 Functional ≤ 10μM
P2RY4_HUMAN P51582 Pyrimidinergic Receptor P2Y4, Human 80 0.34 Functional ≤ 10μM
P2RY4_RAT O35811 Pyrimidinergic Receptor P2Y4, Rat 2600 0.27 Functional ≤ 10μM
P2RY6_HUMAN Q15077 Pyrimidinergic Receptor P2Y6, Human 6000 0.25 Functional ≤ 10μM

Direct Reactome Annotations (via ChEBI)

Description Species
DNA replication initiation
Formation of the active cofactor, UDP-glucuronate
Formation of the Early Elongation Complex
G alpha (i) signalling events
Glycogen synthesis
P2Y receptors
RNA Polymerase I Chain Elongation
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Chain Elongation
Synthesis and interconversion of nucleotide di- and triphosphates
Synthesis of UDP-N-acetyl-glucosamine
Telomere C-strand synthesis initiation

Reactome Annotations from Targets (via Uniprot)

Description Species
G alpha (i) signalling events
G alpha (q) signalling events
P2Y receptors

Analogs ( Draw Identity 99% 90% 80% 70% )