UCSF

ZINC19804780

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Substance Information

In ZINC since Heavy atoms Benign functionality
November 10th, 2008 23 No

Popular Name: (5Z)-5-[[5-(2-bromo-4-nitro-phenyl)-2-furyl]methylene]-2-thioxo-thiazolidin-4-one (5Z)-5-[[5-(2-bromo-4-nitro-phen…

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Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.15 7.13 -50.54 0 6 -1 95 410.25 3 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
PK3CG-2-E PI3-kinase P110-gamma Subunit (cluster #2 Of 3), Eukaryotic Eukaryotes 3600 0.33 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
PK3CG_HUMAN P48736 PI3-kinase P110-gamma Subunit, Human 3600 0.33 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
G beta:gamma signalling through PI3Kgamma
GPVI-mediated activation cascade
Synthesis of PIPs at the plasma membrane

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.