| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 11th, 2004 | 28 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.83 | 7.01 | -61.28 | 1 | 7 | -1 | 97 | 384.408 | 4 | ↓ |
| Mid Mid (pH 6-8) | 2.25 | 2.93 | -14.77 | 2 | 7 | 0 | 98 | 385.416 | 4 | ↓ |
| Mid Mid (pH 6-8) | 2.25 | 2.79 | -17.49 | 2 | 7 | 0 | 98 | 385.416 | 4 | ↓ |
| Mid Mid (pH 6-8) | 0.83 | 6.23 | -17.83 | 2 | 7 | 0 | 94 | 385.416 | 4 | ↓ |
| Mid Mid (pH 6-8) | 0.83 | 6.09 | -21.97 | 2 | 7 | 0 | 94 | 385.416 | 4 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Therapy | antimitotic | SMDC MicroSource |
| Indications | gout | KeyOrganics Bioactives |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2900 | 0.28 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 2900 | 0.28 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | |
| Gap junction assembly | |
| Kinesins | |
| MHC class II antigen presentation | |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
| Mitotic Prometaphase | |
| Post-chaperonin tubulin folding pathway | |
| Prefoldin mediated transfer of substrate to CCT/TriC | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Translocation of GLUT4 to the plasma membrane |
