UCSF

ZINC20983598

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
November 30th, 2008 20 Yes

Popular Name: 5-chloro-N-(2-hydroxy-5-methyl-phenyl)-2-methoxy-benzamide 5-chloro-N-(2-hydroxy-5-methyl-p…

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Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.20 5.71 -14.16 2 4 0 59 291.734 3 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
KCMA1-1-E Calcium-activated Potassium Channel Subunit Alpha-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 28 0.53 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
KCMA1_HUMAN Q12791 Large Conductance Calcium-activated Potassium Channel Subfamily M Alpha Member 1 Isoform B, Human 27.542287 0.53 Binding ≤ 1μM
KCMA1_HUMAN Q12791 Large Conductance Calcium-activated Potassium Channel Subfamily M Alpha Member 1 Isoform B, Human 27.542287 0.53 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Ca2+ activated K+ channels
cGMP effects

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.