| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| December 28th, 2008 | 24 | Yes |
Popular Name: 2-[[2-[4-(2-furylmethyl)piperazin-1-yl]acetyl]amino]thiophene-3-carboxamide 2-[[2-[4-(2-furylmethyl)piperazi…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.59 | 2.35 | -41.07 | 4 | 7 | 1 | 93 | 349.436 | 6 | ↓ |
| Hi High (pH 8-9.5) | 0.59 | -0.19 | -14.11 | 3 | 7 | 0 | 92 | 348.428 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MK08-2-E | Mitogen-activated Protein Kinase 8 (cluster #2 Of 5), Eukaryotic | Eukaryotes | 7600 | 0.30 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MK08_HUMAN | P45983 | C-Jun N-terminal Kinase 1, Human | 7600 | 0.30 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of BIM and translocation to mitochondria | |
| Activation of BMF and translocation to mitochondria | |
| Activation of the AP-1 family of transcription factors | |
| DSCAM interactions | |
| FCERI mediated MAPK activation | |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human | |
| NRAGE signals death through JNK | |
| NRIF signals cell death from the nucleus | |
| Oxidative Stress Induced Senescence |
