| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 27th, 2004 | 32 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.93 | 12.79 | -11.95 | 2 | 8 | 0 | 86 | 432.528 | 9 | ↓ |
| Lo Low (pH 4.5-6) | 4.93 | 13.07 | -35.61 | 3 | 8 | 1 | 87 | 433.536 | 9 | ↓ |
| Lo Low (pH 4.5-6) | 4.93 | 13.18 | -31.89 | 3 | 8 | 1 | 87 | 433.536 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q862F3-2-E | Tubulin Alpha Chain (cluster #2 Of 2), Eukaryotic | Eukaryotes | 8000 | 0.22 | Functional ≤ 10μM |
| Q862L2-2-E | Tubulin Alpha-1 Chain (cluster #2 Of 2), Eukaryotic | Eukaryotes | 8000 | 0.22 | Functional ≤ 10μM |
| TBB2B-2-E | Tubulin Beta Chain (cluster #2 Of 2), Eukaryotic | Eukaryotes | 8000 | 0.22 | Functional ≤ 10μM |
| Z80525-1-O | SW48 (cluster #1 Of 2), Other | Other | 2700 | 0.24 | Functional ≤ 10μM |
| Z80526-1-O | SW480 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other | Other | 4800 | 0.23 | Functional ≤ 10μM |
| Z80874-7-O | CEM (T-cell Leukemia) (cluster #7 Of 7), Other | Other | 5700 | 0.23 | Functional ≤ 10μM |
| Z80928-3-O | HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other | Other | 3300 | 0.24 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z80874 | Z80874 | CEM (T-cell Leukemia) | 5700 | 0.23 | Functional ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 3300 | 0.24 | Functional ≤ 10μM |
| Z80525 | Z80525 | SW48 | 2700 | 0.24 | Functional ≤ 10μM |
| Z80526 | Z80526 | SW480 (Colon Adenocarcinoma Cells) | 4800 | 0.23 | Functional ≤ 10μM |
| Q862F3_BOVIN | Q862F3 | Tubulin Alpha Chain, Bovin | 8000 | 0.22 | Functional ≤ 10μM |
| Q862L2_BOVIN | Q862L2 | Tubulin Alpha-1 Chain, Bovin | 8000 | 0.22 | Functional ≤ 10μM |
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 8000 | 0.22 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | |
| Gap junction assembly | |
| Kinesins | |
| MHC class II antigen presentation | |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
| Mitotic Prometaphase | |
| Post-chaperonin tubulin folding pathway | |
| Prefoldin mediated transfer of substrate to CCT/TriC | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Translocation of GLUT4 to the plasma membrane |
No pre-computed analogs available. Try a structural similarity search.