In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
February 4th, 2009 | 49 | No |
Popular Name: L-685,458 L-685,458
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 7.46 | 10.74 | -21.78 | 6 | 10 | 0 | 160 | 672.867 | 19 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
BACE1-1-E | Beta-secretase 1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 300 | 0.19 | Binding ≤ 10μM |
BACE2-1-E | Beta Secretase 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 300 | 0.19 | Binding ≤ 10μM |
PEN2-1-E | Gamma-secretase Subunit PEN-2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 300 | 0.19 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
BACE2_HUMAN | Q9Y5Z0 | Beta Secretase 2, Human | 300 | 0.19 | Binding ≤ 1μM |
BACE1_HUMAN | P56817 | Beta-secretase 1, Human | 300 | 0.19 | Binding ≤ 1μM |
PEN2_HUMAN | Q9NZ42 | Gamma-secretase Subunit PEN-2, Human | 300 | 0.19 | Binding ≤ 1μM |
BACE2_HUMAN | Q9Y5Z0 | Beta Secretase 2, Human | 300 | 0.19 | Binding ≤ 10μM |
BACE1_HUMAN | P56817 | Beta-secretase 1, Human | 300 | 0.19 | Binding ≤ 10μM |
PEN2_HUMAN | Q9NZ42 | Gamma-secretase Subunit PEN-2, Human | 300 | 0.19 | Binding ≤ 10μM |
Description | Species |
---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | |
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |
EPH-ephrin mediated repulsion of cells | |
NOTCH2 Activation and Transmission of Signal to the Nucleus | |
NRIF signals cell death from the nucleus | |
Nuclear signaling by ERBB4 | |
Regulated proteolysis of p75NTR | |
Signaling by NOTCH3 | |
Signaling by NOTCH4 |