| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 7th, 2009 | 41 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 8.83 | 19.86 | -55.34 | 0 | 4 | -1 | 58 | 582.189 | 9 | ↓ |
| Lo Low (pH 4.5-6) | 8.83 | 20.14 | -71.31 | 1 | 4 | 0 | 59 | 583.197 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AL5AP-1-E | 5-lipoxygenase Activating Protein (cluster #1 Of 1), Eukaryotic | Eukaryotes | 11 | 0.27 | Binding ≤ 10μM |
| Z50587-1-O | Homo Sapiens (cluster #1 Of 9), Other | Other | 12 | 0.27 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AL5AP_HUMAN | P20292 | 5-lipoxygenase Activating Protein, Human | 11 | 0.27 | Binding ≤ 1μM |
| AL5AP_HUMAN | P20292 | 5-lipoxygenase Activating Protein, Human | 11 | 0.27 | Binding ≤ 10μM |
| Z50587 | Z50587 | Homo Sapiens | 12 | 0.27 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Synthesis of 5-eicosatetraenoic acids | |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | |
| Synthesis of Lipoxins (LX) |
