| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 7th, 2009 | 33 | Yes |
Popular Name: PD-32577 PD-32577
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.59 | 13.7 | -65.9 | 3 | 4 | 1 | 52 | 451.675 | 6 | ↓ |
| Mid Mid (pH 6-8) | 6.59 | 13.19 | -90.95 | 4 | 4 | 2 | 49 | 452.683 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CAC1B-1-E | Voltage-gated N-type Calcium Channel Alpha-1B Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 970 | 0.26 | Functional ≤ 10μM |
| CAC1C-1-E | Voltage-gated L-type Calcium Channel Alpha-1C Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.24 | Functional ≤ 10μM |
| CAC1D-1-E | Voltage-gated L-type Calcium Channel Alpha-1D Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.24 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CAC1C_RAT | P22002 | Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat | 2000 | 0.24 | Functional ≤ 10μM |
| CAC1D_RAT | P27732 | Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat | 2000 | 0.24 | Functional ≤ 10μM |
| CAC1B_HUMAN | Q00975 | Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human | 970 | 0.26 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Chann |
