| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 23rd, 2004 | 21 | Yes |
Popular Name: (3-amino-4,6-dimethyl-furo[2,3-b]pyridin-2-yl)-(4-fluorophenyl)methanone (3-amino-4,6-dimethyl-furo[2,3-b…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.45 | -0.37 | -9.57 | 2 | 4 | 0 | 69 | 284.29 | 2 | ↓ |
| Lo Low (pH 4.5-6) | 3.45 | 0.24 | -34.87 | 3 | 4 | 1 | 70 | 285.298 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM5-2-E | Metabotropic Glutamate Receptor 5 (cluster #2 Of 5), Eukaryotic | Eukaryotes | 410 | 0.43 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 410 | 0.43 | Binding ≤ 1μM |
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 410 | 0.43 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (q) signalling events |
