In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
February 15th, 2009 | 23 | Yes |
Popular Name: 6,7-dimethoxy-N-methyl-N-(p-tolyl)quinazolin-4-amine 6,7-dimethoxy-N-methyl-N-(p-toly…
None
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.53 | 9.16 | -9.27 | 0 | 5 | 0 | 47 | 309.369 | 4 | ↓ |
Lo Low (pH 4.5-6) | 3.53 | 9.61 | -36.33 | 1 | 5 | 1 | 49 | 310.377 | 4 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
CSF1R-1-E | Macrophage Colony Stimulating Factor Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.35 | Functional ≤ 10μM |
EGFR-1-E | Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4000 | 0.33 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
EGFR_HUMAN | P00533 | Epidermal Growth Factor Receptor ErbB1, Human | 4000 | 0.33 | Functional ≤ 10μM |
CSF1R_HUMAN | P07333 | Macrophage Colony Stimulating Factor Receptor, Human | 2000 | 0.35 | Functional ≤ 10μM |
Description | Species |
---|---|
Constitutive PI3K/AKT Signaling in Cancer | |
EGFR downregulation | |
EGFR interacts with phospholipase C-gamma | |
EGFR Transactivation by Gastrin | |
GAB1 signalosome | |
GRB2 events in EGFR signaling | |
GRB2 events in ERBB2 signaling | |
PI3K events in ERBB2 signaling | |
PIP3 activates AKT signaling | |
PLCG1 events in ERBB2 signaling | |
SHC1 events in EGFR signaling | |
SHC1 events in ERBB2 signaling | |
Signal transduction by L1 | |
Signaling by constitutively active EGFR | |
Signaling by EGFR | |
Signaling by ERBB2 | |
Signaling by ERBB4 |