| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 21st, 2009 | 39 | No |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.51 | 12.33 | -57.3 | 4 | 7 | 1 | 84 | 562.012 | 9 | ↓ |
| Hi High (pH 8-9.5) | 6.51 | 10.04 | -22.42 | 3 | 7 | 0 | 83 | 561.004 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| RAF1-1-E | Serine/threonine-protein Kinase RAF (cluster #1 Of 1), Eukaryotic | Eukaryotes | 82 | 0.25 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| RAF1_HUMAN | P04049 | Serine/threonine-protein Kinase RAF, Human | 82 | 0.25 | Binding ≤ 1μM |
| RAF1_HUMAN | P04049 | Serine/threonine-protein Kinase RAF, Human | 82 | 0.25 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| CREB phosphorylation through the activation of Ras | |
| GP1b-IX-V activation signalling | |
| MEK activation | |
| RAF activation | |
| RAF phosphorylates MEK | |
| Rap1 signalling | |
| Stimuli-sensing channels |
