| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 23rd, 2009 | 30 | Yes |
Popular Name: N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-4-methoxy-aniline N-[4-[(6,7-dimethoxy-4-quinolyl)…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.60 | 9.07 | -40.02 | 2 | 6 | 1 | 63 | 403.458 | 7 | ↓ |
| Hi High (pH 8-9.5) | 5.60 | 8.66 | -11.53 | 1 | 6 | 0 | 62 | 402.45 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FGFR2-1-E | Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 780 | 0.29 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 780 | 0.29 | Binding ≤ 1μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 780 | 0.29 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activated point mutants of FGFR2 | |
| Signaling by FGFR mutants | |
| Signaling by FGFR2 amplification mutants |
