| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 27th, 2009 | 24 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.13 | 8.47 | -25.43 | 1 | 3 | 1 | 21 | 318.444 | 2 | ↓ |
| Hi High (pH 8-9.5) | 4.13 | 8.13 | -10.33 | 0 | 3 | 0 | 19 | 317.436 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TERT-1-E | Telomerase Reverse Transcriptase (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5200 | 0.31 | Binding ≤ 10μM |
| Z80493-3-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #3 Of 6), Other | Other | 8200 | 0.30 | Functional ≤ 10μM |
| Z80768-1-O | CH1 (Ovarian Carcinoma Cells) (cluster #1 Of 1), Other | Other | 8200 | 0.30 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TERT_HUMAN | O14746 | Telomerase Reverse Transcriptase, Human | 5200 | 0.31 | Binding ≤ 10μM |
| Z80768 | Z80768 | CH1 (Ovarian Carcinoma Cells) | 8200 | 0.30 | Functional ≤ 10μM |
| Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 2600 | 0.33 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| formation of the beta-catenin:TCF transactivating complex | |
| Telomere Extension By Telomerase |
