In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
February 28th, 2009 | 22 | No |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 1.97 | 9.24 | -54.25 | 0 | 5 | -1 | 84 | 297.286 | 6 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ERCC5-2-E | DNA Excision Repair Protein ERCC-5 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 1590 | 0.37 | Binding ≤ 10μM |
FEN1-2-E | Flap Endonuclease 1 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 1360 | 0.37 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ERCC5_HUMAN | P28715 | DNA Excision Repair Protein ERCC-5, Human | 1590 | 0.37 | Binding ≤ 10μM |
FEN1_HUMAN | P39748 | Flap Endonuclease 1, Human | 1360 | 0.37 | Binding ≤ 10μM |
Description | Species |
---|---|
Dual incision reaction in GG-NER | |
Dual incision reaction in TC-NER | |
Formation of incision complex in GG-NER | |
Formation of transcription-coupled NER (TC-NER) repair complex | |
Removal of DNA patch containing abasic residue | |
Removal of the Flap Intermediate | |
Removal of the Flap Intermediate from the C-strand |