In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
March 1st, 2009 | 26 | Yes |
Popular Name: 4-[3-[[(2S)-1-methylpyrrolidin-2-yl]methyl]indol-1-yl]sulfonylaniline 4-[3-[[(2S)-1-methylpyrrolidin-2…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 2.74 | 8.03 | -47.24 | 3 | 5 | 1 | 70 | 370.498 | 4 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
5HT6R-2-E | Serotonin 6 (5-HT6) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3 | 0.46 | Binding ≤ 10μM |
5HT6R-1-E | 5-hydroxytryptamine Receptor 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 25 | 0.41 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 3 | 0.46 | Binding ≤ 1μM |
5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 3 | 0.46 | Binding ≤ 10μM |
5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 24.5 | 0.41 | Functional ≤ 10μM |
Description | Species |
---|---|
G alpha (s) signalling events | |
Serotonin receptors |