| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 5th, 2009 | 24 | Yes |
Popular Name: 2-[2-(4-methoxyphenyl)-4-pyridyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one 2-[2-(4-methoxyphenyl)-4-pyridyl…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.59 | 5.51 | -19.95 | 2 | 5 | 0 | 67 | 319.364 | 3 | ↓ |
| Lo Low (pH 4.5-6) | 2.59 | 5.85 | -49.71 | 3 | 5 | 1 | 68 | 320.372 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MAPK2-1-E | MAP Kinase-activated Protein Kinase 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 55 | 0.42 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MAPK2_HUMAN | P49137 | MAP Kinase-activated Protein Kinase 2, Human | 55 | 0.42 | Binding ≤ 1μM |
| MAPK2_HUMAN | P49137 | MAP Kinase-activated Protein Kinase 2, Human | 55 | 0.42 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| activated TAK1 mediates p38 MAPK activation | |
| Butyrate Response Factor 1 (BRF1) destabilizes mRNA | |
| CREB phosphorylation | |
| Oxidative Stress Induced Senescence | |
| p38MAPK events | |
| Regulation of HSF1-mediated heat shock response | |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | |
| Tristetraprolin (TTP) destabilizes mRNA | |
| VEGFA-VEGFR2 Pathway |
