| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 11th, 2009 | 30 | Yes |
Popular Name: 4-(4-anilinoanilino)-6,7-dimethoxy-quinoline-3-carbonitrile 4-(4-anilinoanilino)-6,7-dimetho…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.52 | 9.54 | -11.33 | 2 | 6 | 0 | 79 | 396.45 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MP2K1-3-E | Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 160 | 0.32 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MP2K1_HUMAN | Q02750 | Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human | 160 | 0.32 | Binding ≤ 1μM |
| MP2K1_HUMAN | Q02750 | Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human | 1200 | 0.28 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| ERK1 activation | |
| Interleukin-1 signaling | |
| MEK activation | |
| RAF phosphorylates MEK | |
| Signal transduction by L1 | |
| Signaling by FGFR | |
| Uptake and function of anthrax toxins |
