| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 14th, 2009 | 44 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 8.20 | 20.11 | -59.48 | 3 | 5 | 1 | 66 | 595.896 | 15 | ↓ |
| Lo Low (pH 4.5-6) | 8.20 | 20.54 | -102.28 | 4 | 5 | 2 | 67 | 596.904 | 15 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GNRHR-1-E | Gonadotropin-releasing Hormone Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.27 | Binding ≤ 10μM |
| GNRHR-1-E | Gonadotropin-releasing Hormone Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 140 | 0.22 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GNRHR_RAT | P30969 | Gonadotropin-releasing Hormone Receptor, Rat | 2.8 | 0.27 | Binding ≤ 1μM |
| GNRHR_RAT | P30969 | Gonadotropin-releasing Hormone Receptor, Rat | 2.8 | 0.27 | Binding ≤ 10μM |
| GNRHR_RAT | P30969 | Gonadotropin-releasing Hormone Receptor, Rat | 140 | 0.22 | Functional ≤ 10μM |
| GNRHR_HUMAN | P30968 | Gonadotropin-releasing Hormone Receptor, Human | 8.3 | 0.26 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (q) signalling events | |
| Hormone ligand-binding receptors |
