Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.44	1.18	-61.41	4	6	1	83	345.419	1	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	0.44	-1.06	-15.71	3	6	0	82	344.411	1	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	700	0.34	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	4400	0.30	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	63	0.40	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	46	0.41	Functional ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	46	0.41	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	700	0.34	Binding ≤ 1μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	63	0.40	Binding ≤ 1μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	700	0.34	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	4400	0.30	Binding ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	63	0.40	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	45.9	0.41	Functional ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	45.9	0.41	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN)
G-protein activation	Homo sapiens (OPRM_HUMAN)
Opioid Signalling	Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Homo sapiens (OPRM_HUMAN)