| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 15th, 2009 | 44 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.91 | 9.48 | -91.33 | 8 | 10 | 2 | 154 | 612.86 | 19 | ↓ |
| Mid Mid (pH 6-8) | 2.91 | 9.05 | -62.58 | 7 | 10 | 1 | 153 | 611.852 | 19 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMT1-1-E | Peptide N-myristoyltransferase 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8000 | 0.16 | Binding ≤ 10μM |
| NMT1-1-E | Peptide N-myristoyltransferase 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8200 | 0.16 | Binding ≤ 10μM |
| NMT2-1-E | Peptide N-myristoyltransferase 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8000 | 0.16 | Binding ≤ 10μM |
| NMT2-1-E | Peptide N-myristoyltransferase 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8200 | 0.16 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMT1_HUMAN | P30419 | Peptide N-myristoyltransferase 1, Human | 40 | 0.24 | Binding ≤ 1μM |
| NMT2_HUMAN | O60551 | Peptide N-myristoyltransferase 2, Human | 40 | 0.24 | Binding ≤ 1μM |
| NMT1_HUMAN | P30419 | Peptide N-myristoyltransferase 1, Human | 40 | 0.24 | Binding ≤ 10μM |
| NMT2_HUMAN | O60551 | Peptide N-myristoyltransferase 2, Human | 40 | 0.24 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation, myristolyation of BID and translocation to mitochondria | |
| Inactivation, recovery and regulation of the phototransduction cascade | |
| Late Phase of HIV Life Cycle | |
| Membrane binding and targetting of GAG proteins |
