In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
July 23rd, 2004 | 17 | Yes |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 2.66 | 4.09 | -10.67 | 2 | 3 | 0 | 49 | 227.263 | 2 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
HDAC1-1-E | Histone Deacetylase 1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 4800 | 0.44 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
HDAC1_HUMAN | Q13547 | Histone Deacetylase 1, Human | 4800 | 0.44 | Binding ≤ 10μM |
Description | Species |
---|---|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |
deactivation of the beta-catenin transactivating complex | |
Downregulation of SMAD2/3:SMAD4 transcriptional activity | |
Factors involved in megakaryocyte development and platelet production | |
formation of the beta-catenin:TCF transactivating complex | |
G0 and Early G1 | |
HDACs deacetylate histones | |
NoRC negatively regulates rRNA expression | |
NOTCH1 Intracellular Domain Regulates Transcription | |
p75NTR negatively regulates cell cycle via SC1 | |
repression of WNT target genes | |
RNA Polymerase I Transcription Initiation | |
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |