UCSF

ZINC03280663

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Substance Information

In ZINC since Heavy atoms Benign functionality
November 7th, 2004 24 No

Popular Name: (3Z)-5-chloro-3-(4-morpholinobenzylidene)oxindole (3Z)-5-chloro-3-(4-morpholinoben…

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Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.73 -3.55 -8.92 1 4 0 45 340.81 2 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
VGFR1-1-E Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 4100 0.31 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
VGFR1_MOUSE P35969 Vascular Endothelial Growth Factor Receptor 1, Mouse 4100 0.31 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.