In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
September 1st, 2009 | 30 | No |
Popular Name: DNC014827 DNC014827
None
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | -3.52 | -1.01 | -365.44 | 3 | 16 | -4 | 261 | 485.179 | 8 | ↓ |
Mid Mid (pH 6-8) | -3.52 | -2.17 | -227.63 | 4 | 16 | -3 | 258 | 486.187 | 8 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
DPOLB-1-E | DNA Polymerase Beta (cluster #1 Of 3), Eukaryotic | Eukaryotes | 5000 | 0.25 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
DPOLB_HUMAN | P06746 | DNA Polymerase Beta, Human | 5000 | 0.25 | Binding ≤ 10μM |
Description | Species |
---|---|
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway | |
Removal of DNA patch containing abasic residue | |
Resolution of AP sites via the single-nucleotide replacement pathway |