| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 25th, 2009 | 25 | No |
Popular Name: [(2S,3R)-2-(hydroxymethyl)-6-oxo-tetrahydropyran-3-yl] [(2S,3R)-2-(hydroxymethyl)-6-oxo…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.66 | 11.21 | -10.72 | 1 | 5 | 0 | 73 | 356.503 | 15 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA-2-E | Protein Kinase C Alpha (cluster #2 Of 6), Eukaryotic | Eukaryotes | 2800 | 0.31 | Binding ≤ 10μM |
| KPCB-1-E | Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 2800 | 0.31 | Binding ≤ 10μM |
| KPCD-2-E | Protein Kinase C Delta (cluster #2 Of 4), Eukaryotic | Eukaryotes | 2800 | 0.31 | Binding ≤ 10μM |
| KPCG-1-E | Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic | Eukaryotes | 2800 | 0.31 | Binding ≤ 10μM |
| KPCL-1-E | Protein Kinase C Eta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 2800 | 0.31 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA_MOUSE | P20444 | Protein Kinase C Alpha, Mouse | 2800 | 0.31 | Binding ≤ 10μM |
| KPCB_MOUSE | P68404 | Protein Kinase C Beta, Mouse | 2800 | 0.31 | Binding ≤ 10μM |
| KPCD_MOUSE | P28867 | Protein Kinase C Delta, Mouse | 2800 | 0.31 | Binding ≤ 10μM |
| KPCL_MOUSE | P23298 | Protein Kinase C Eta, Mouse | 2800 | 0.31 | Binding ≤ 10μM |
| KPCG_MOUSE | P63318 | Protein Kinase C Gamma, Mouse | 2800 | 0.31 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of NF-kappaB in B cells | |
| Apoptotic cleavage of cellular proteins | |
| Calmodulin induced events | |
| DAG and IP3 signaling | |
| Depolymerisation of the Nuclear Lamina | |
| Disinhibition of SNARE formation | |
| Effects of PIP2 hydrolysis | |
| G alpha (z) signalling events | |
| HuR stabilizes mRNA | |
| Interferon gamma signaling | |
| Response to elevated platelet cytosolic Ca2+ | |
| Role of phospholipids in phagocytosis | |
| Trafficking of GluR2-containing AMPA receptors | |
| VEGFR2 mediated cell proliferation | |
| WNT5A-dependent internalization of FZD4 |
