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Activation of ATR in response to replication stress |
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Activation of NIMA Kinases NEK9, NEK6, NEK7 |
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Activation of the pre-replicative complex |
|
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APC/C:Cdc20 mediated degradation of Cyclin B |
|
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CDK-mediated phosphorylation and removal of Cdc6 |
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
|
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Condensation of Prometaphase Chromosomes |
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Condensation of Prophase Chromosomes |
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Cyclin A/B1 associated events during G2/M transition |
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Cyclin A:Cdk2-associated events at S phase entry |
|
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Cyclin B2 mediated events |
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Cyclin E associated events during G1/S transition |
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Depolymerisation of the Nuclear Lamina |
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DNA Damage/Telomere Stress Induced Senescence |
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E2F mediated regulation of DNA replication |
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E2F-enabled inhibition of pre-replication complex formation |
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ERK1 activation |
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Factors involved in megakaryocyte development and platelet production |
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G0 and Early G1 |
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G1/S-Specific Transcription |
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G2 Phase |
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G2/M DNA replication checkpoint |
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Golgi Cisternae Pericentriolar Stack Reorganization |
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Loss of Nlp from mitotic centrosomes |
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Loss of proteins required for interphase microtubule organization from the ce |
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|
MASTL Facilitates Mitotic Progression |
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Meiotic recombination |
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Nuclear Pore Complex (NPC) Disassembly |
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|
Orc1 removal from chromatin |
|
|
p53-Dependent G1 DNA Damage Response |
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Phosphorylation of Emi1 |
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Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 |
|
|
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 com |
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Phosphorylation of the APC/C |
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Recruitment of mitotic centrosome proteins and complexes |
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|
Recruitment of NuMA to mitotic centrosomes |
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|
Regulation of APC/C activators between G1/S and early anaphase |
|
|
Regulation of PLK1 Activity at G2/M Transition |
|
|
Resolution of Sister Chromatid Cohesion |
|
|
SCF(Skp2)-mediated degradation of p27/p21 |
|
|
Senescence-Associated Secretory Phenotype (SASP) |
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