Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	6.38	11.38	-60.45	1	9	-1	131	595.767	10	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	6.38	11.62	-51.27	3	9	1	129	597.783	10	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
BAD-1-E	Bcl2-antagonist Of Cell Death (BAD) (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.22	Binding ≤ 10μM
BCL2-1-E	Apoptosis Regulator Bcl-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	67	0.24	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
BCL2_HUMAN	P10415	Apoptosis Regulator Bcl-2, Human	67	0.24	Binding ≤ 1μM
BAD_HUMAN	Q92934	Bcl2-antagonist Of Cell Death (BAD), Human	0.8	0.31	Binding ≤ 1μM
BCL2_HUMAN	P10415	Apoptosis Regulator Bcl-2, Human	67	0.24	Binding ≤ 10μM
BAD_HUMAN	Q92934	Bcl2-antagonist Of Cell Death (BAD), Human	0.8	0.31	Binding ≤ 10μM

Description	Species
Activation of BAD and translocation to mitochondria	Homo sapiens (BCL2_HUMAN)
AKT phosphorylates targets in the cytosol	Homo sapiens (BAD_HUMAN)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	Homo sapiens (BCL2_HUMAN)
Constitutive PI3K/AKT Signaling in Cancer	Homo sapiens (BAD_HUMAN)
NRAGE signals death through JNK	Homo sapiens (BAD_HUMAN)
The NLRP1 inflammasome	Homo sapiens (BCL2_HUMAN)