Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.18	9.04	-109.2	5	5	2	65	449.639	12	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.18	7.5	-7.34	3	5	0	59	447.623	12	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.18	7.83	-42.96	4	5	1	60	448.631	12	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.18	8.95	-53.2	4	5	1	64	448.631	12	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.18	8.87	-119.19	5	5	2	61	449.639	12	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	8260	0.22	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	2358	0.24	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	38	0.31	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	38	0.31	Binding ≤ 1μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	8260	0.22	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	2358	0.24	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	38	0.31	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRD_HUMAN) Rattus norvegicus (OPRM_RAT)
G-protein activation	Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Homo sapiens (OPRD_HUMAN) Rattus norvegicus (OPRM_RAT)