Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.59	9.8	-135.94	5	5	2	66	443.591	4	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.59	6.51	-7.41	3	5	0	61	441.575	4	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.59	8.81	-45.85	4	5	1	62	442.583	4	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.59	7.94	-42.53	4	5	1	65	442.583	4	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	1	0.38	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	57	0.31	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	90	0.30	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	0.77	0.39	Binding ≤ 1μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	57.3	0.31	Binding ≤ 1μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	90.3	0.30	Binding ≤ 1μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	0.77	0.39	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	57.3	0.31	Binding ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	90.3	0.30	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN)
G-protein activation	Homo sapiens (OPRM_HUMAN)
Opioid Signalling	Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Homo sapiens (OPRM_HUMAN)