| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 26th, 2009 | 28 | No |
Popular Name: (1S,3R)-3-hexadecyl-1,5,5-trimethyl-2,8-dioxa-5-azonia-1$l^{5}-phosphacyclooctane (1S,3R)-3-hexadecyl-1,5,5-trimet…
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| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.51 | 17.36 | -44.71 | 0 | 4 | 1 | 36 | 418.623 | 15 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA-3-E | Protein Kinase C Alpha (cluster #3 Of 6), Eukaryotic | Eukaryotes | 4800 | 0.27 | Binding ≤ 10μM |
| KPCB-4-E | Protein Kinase C Beta (cluster #4 Of 4), Eukaryotic | Eukaryotes | 4800 | 0.27 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA_MOUSE | P20444 | Protein Kinase C Alpha, Mouse | 4800 | 0.27 | Binding ≤ 10μM |
| KPCB_MOUSE | P68404 | Protein Kinase C Beta, Mouse | 4800 | 0.27 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of NF-kappaB in B cells | |
| Depolymerisation of the Nuclear Lamina | |
| Disinhibition of SNARE formation | |
| G alpha (z) signalling events | |
| Response to elevated platelet cytosolic Ca2+ | |
| Trafficking of GluR2-containing AMPA receptors | |
| VEGFR2 mediated cell proliferation | |
| WNT5A-dependent internalization of FZD4 |
