| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 29th, 2005 | 25 | Yes |
Popular Name: 10-[(3-hydroxy-4-methoxy-phenyl)methylene]anthracen-9-one 10-[(3-hydroxy-4-methoxy-phenyl)…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.86 | 8.97 | -14.3 | 1 | 3 | 0 | 47 | 328.367 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBA1A-1-E | Tubulin Alpha-3 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 370 | 0.36 | Binding ≤ 10μM |
| TBB-1-E | Tubulin Beta Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 370 | 0.36 | Binding ≤ 10μM |
| TBA1A-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 670 | 0.35 | Functional ≤ 10μM |
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 670 | 0.35 | Functional ≤ 10μM |
| Z50590-1-O | Sus Scrofa (cluster #1 Of 1), Other | Other | 700 | 0.34 | Functional ≤ 10μM |
| Z80186-2-O | K562 (Erythroleukemia Cells) (cluster #2 Of 11), Other | Other | 206 | 0.37 | Functional ≤ 10μM |
| Z80193-1-O | L1210 (Lymphocytic Leukemia Cells) (cluster #1 Of 12), Other | Other | 140 | 0.38 | Functional ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 10 | 0.45 | Functional ≤ 10μM |
| Z80364-1-O | P388/ADR (Lymphoma Cells) (cluster #1 Of 1), Other | Other | 260 | 0.37 | Functional ≤ 10μM |
| Z80427-1-O | RKO (Colon Carcinoma) (cluster #1 Of 1), Other | Other | 60 | 0.40 | Functional ≤ 10μM |
| Z80441-1-O | RXF 944 (cluster #1 Of 1), Other | Other | 10 | 0.45 | Functional ≤ 10μM |
| Z80493-1-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #1 Of 6), Other | Other | 50 | 0.41 | Functional ≤ 10μM |
| Z81006-1-O | Human Breast 401NL Tumor Cell Line (cluster #1 Of 1), Other | Other | 10 | 0.45 | Functional ≤ 10μM |
| Z81024-5-O | NCI-H460 (Non-small Cell Lung Carcinoma) (cluster #5 Of 8), Other | Other | 70 | 0.40 | Functional ≤ 10μM |
| Z81025-1-O | Human Lung LXF 529L Tumor Cell Line (cluster #1 Of 1), Other | Other | 520 | 0.35 | Functional ≤ 10μM |
| Z81026-1-O | Human Lung LXF 629L Tumor Cell Line (cluster #1 Of 1), Other | Other | 10 | 0.45 | Functional ≤ 10μM |
| Z81054-2-O | SF-268 (Glioblastoma Cells) (cluster #2 Of 3), Other | Other | 50 | 0.41 | Functional ≤ 10μM |
| Z81115-1-O | KB (Squamous Cell Carcinoma) (cluster #1 Of 6), Other | Other | 90 | 0.39 | Functional ≤ 10μM |
| Z81187-1-O | LT12 Tumor Cell Line (cluster #1 Of 1), Other | Other | 320 | 0.36 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 370 | 0.36 | Binding ≤ 1μM |
| TBB_PIG | P02554 | Tubulin Beta Chain, Pig | 370 | 0.36 | Binding ≤ 1μM |
| TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 370 | 0.36 | Binding ≤ 10μM |
| TBB_PIG | P02554 | Tubulin Beta Chain, Pig | 370 | 0.36 | Binding ≤ 10μM |
| Z81006 | Z81006 | Human Breast 401NL Tumor Cell Line | 10 | 0.45 | Functional ≤ 10μM |
| Z81025 | Z81025 | Human Lung LXF 529L Tumor Cell Line | 520 | 0.35 | Functional ≤ 10μM |
| Z81026 | Z81026 | Human Lung LXF 629L Tumor Cell Line | 10 | 0.45 | Functional ≤ 10μM |
| Z80186 | Z80186 | K562 (Erythroleukemia Cells) | 20 | 0.43 | Functional ≤ 10μM |
| Z81115 | Z81115 | KB (Squamous Cell Carcinoma) | 90 | 0.39 | Functional ≤ 10μM |
| Z80193 | Z80193 | L1210 (Lymphocytic Leukemia Cells) | 130 | 0.39 | Functional ≤ 10μM |
| Z81187 | Z81187 | LT12 Tumor Cell Line | 190 | 0.38 | Functional ≤ 10μM |
| Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 10 | 0.45 | Functional ≤ 10μM |
| Z81024 | Z81024 | NCI-H460 (Non-small Cell Lung Carcinoma) | 10 | 0.45 | Functional ≤ 10μM |
| Z80364 | Z80364 | P388/ADR (Lymphoma Cells) | 160 | 0.38 | Functional ≤ 10μM |
| Z80427 | Z80427 | RKO (Colon Carcinoma) | 60 | 0.40 | Functional ≤ 10μM |
| Z80441 | Z80441 | RXF 944 | 10 | 0.45 | Functional ≤ 10μM |
| Z81054 | Z81054 | SF-268 (Glioblastoma Cells) | 30 | 0.42 | Functional ≤ 10μM |
| Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 50 | 0.41 | Functional ≤ 10μM |
| Z50590 | Z50590 | Sus Scrofa | 670 | 0.35 | Functional ≤ 10μM |
| TBA1A_RAT | P68370 | Tubulin Alpha-1 Chain, Rat | 670 | 0.35 | Functional ≤ 10μM |
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 670 | 0.35 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | |
| Gap junction assembly | |
| Kinesins | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| MHC class II antigen presentation | |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
| Mitotic Prometaphase | |
| Post-chaperonin tubulin folding pathway | |
| Prefoldin mediated transfer of substrate to CCT/TriC | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Regulation of PLK1 Activity at G2/M Transition | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Translocation of GLUT4 to the plasma membrane |
No pre-computed analogs available. Try a structural similarity search.