UCSF

ZINC38536757

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Substance Information

In ZINC since Heavy atoms Benign functionality
January 26th, 2010 21 No

Popular Name: 2-hydroxy-N-(2-methoxy-4-nitro-phenyl)benzamide 2-hydroxy-N-(2-methoxy-4-nitro-p…

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Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.26 5.07 -11.06 2 7 0 104 288.259 4 ↓
Hi High (pH 8-9.5) 3.26 6.08 -50.21 1 7 -1 107 287.251 4 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
KCMA1-1-E Calcium-activated Potassium Channel Subunit Alpha-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 191 0.45 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
KCMA1_HUMAN Q12791 Large Conductance Calcium-activated Potassium Channel Subfamily M Alpha Member 1 Isoform B, Human 190.546072 0.45 Binding ≤ 1μM
KCMA1_HUMAN Q12791 Large Conductance Calcium-activated Potassium Channel Subfamily M Alpha Member 1 Isoform B, Human 190.546072 0.45 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Ca2+ activated K+ channels
cGMP effects

Analogs ( Draw Identity 99% 90% 80% 70% )