| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 3rd, 2005 | 18 | No |
Popular Name: 1-Amino-4-hydroxyanthraquinone 1-Amino-4-hydroxyanthraquinone
Find On: PubMed — Wikipedia — Google
CAS Numbers: 116-85-8 , [116-85-8]
1-amino-4-hydroxyanthracene-9,10-dione
1-Amino-4-hydroxyanthraquinone, 96%
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.84 | 4.1 | -9.46 | 3 | 4 | 0 | 80 | 239.23 | 0 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Mp [°C] | 207 - 209 | Acros Organics |
| Melting_Point | 207-209? | Alfa-Aesar |
| Melting_Point | 207-209° | Alfa-Aesar |
| MP | 215 | TCI |
| H phrase | H351: Suspected of causing cancer | Acros Organics |
| H phrase | H351: Suspected of causing cancer; H341: Suspected of causing genetic defects; H371: May cause damage to organs; H304: May be fatal if swallowed and enters airways | Acros Organics |
| P phrase | P281: Use personal protective equipment as required | Acros Organics |
| P phrase | P281: Use personal protective equipment as required; P260: Do not breathe dust/fume/gas/mist/vapors/spray; P301+ P310: IF SWALLOWED: Immediately call a POISON CENTRE or doctor/physician; P331: Do NOT induce vomiting | Acros Organics |
| R phrase | R40: Limited evidence of a carcinogenic effect. | Acros Organics |
| R phrase | R40: Limited evidence of a carcinogenic effect.; R65: Harmful: may cause lung damage if swallowed.; R68: Possible risks of irreversible effects. | Acros Organics |
| S phrase | S36/37: Wear suitable protective clothing and gloves. | Acros Organics |
| Hazard | XN: Harmful | Acros Organics |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KC1A-1-E | Casein Kinase I Alpha (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4000 | 0.42 | Binding ≤ 10μM |
| KC1D-1-E | Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 660 | 0.48 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KC1D_HUMAN | P48730 | Casein Kinase I Delta, Human | 660 | 0.48 | Binding ≤ 1μM |
| KC1A_HUMAN | P48729 | Casein Kinase I Alpha, Human | 4000 | 0.42 | Binding ≤ 10μM |
| KC1D_HUMAN | P48730 | Casein Kinase I Delta, Human | 660 | 0.48 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| APC truncation mutants have impaired AXIN binding | |
| AXIN missense mutants destabilize the destruction complex | |
| Beta-catenin phosphorylation cascade | |
| Circadian Clock | |
| Degradation of beta-catenin by the destruction complex | |
| disassembly of the destruction complex and recruitment of AXIN to the membrane | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| misspliced GSK3beta mutants stabilize beta-catenin | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Regulation of PLK1 Activity at G2/M Transition | |
| S33 mutants of beta-catenin aren't phosphorylated | |
| S37 mutants of beta-catenin aren't phosphorylated | |
| S45 mutants of beta-catenin aren't phosphorylated | |
| T41 mutants of beta-catenin aren't phosphorylated | |
| truncations of AMER1 destabilize the destruction complex |
