UCSF

ZINC03869850

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
October 4th, 2005 11 No

Popular Name: L-Dihydroorotic acid L-Dihydroorotic acid

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CAS Numbers: 155-54-4; 5988-19-2 , 5988-19-2 , 6202-10-4 , [5988-19-2]

Other Names:

(+)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylate;(+)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid;(R)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylate;(R)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid;(S)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylate;(S

(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID; (S)-4,5-Dihydroorotate; (S)-4,5-dihydroorotic acid; (S)-Dihydroorotate; (S)-dihydroorotic acid; 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid; DOR; Dihydro-L-orotic acid; Dihydroorotic Acid; L-Dihydroo

(4S)-Hexahydro-2,6-dioxo-4-pyrimidinecarboxylic acid

(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid; (S)-4,5-Dihydroorotate; (S)-Dihydroorotate; 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid; 4,5-dihydro-L-orotate; 5-dihydroorotate; Dihydro-L-orotate; Dihydro-L-orotic acid; L-Dihydroorotate; L-Dihydroo

(S)-2,6-Dioxohexahydropyrimidine-4-carboxylic acid

(S)-4,5-dihydroorotate; (S)-4,5-dihydroorotic acid; (S)-4-pyrimidinecarboxylic acid; (S)-di-H-orotate; (S)-dihydroorotate; (S)-hydroorotic acid; 155-54-4; 4,5-dihydro-L-orotate; 5988-19-2; DI-H-OROTATE; L-4,5-dihydroorotate; L-dihydroorotate; dihydro-L-or

(S)-4,5-Dihydroorotate; (S)-Dihydroorotate; 4,5-Dihydroorotate; 4,5-Dihydroorotic acid; 5,6-Dihydroorotate; Dihydro-L-orotic acid; L-Dihydroorotate; L-Dihydroorotic acid; L-hydroorotate; L-hydroorotic acid; R,S-Hydroorotate

(S)-4,5-Dihydroorotate; (S)-Dihydroorotate; 5988-19-2; C00337; Dihydro-L-orotic acid; L-Dihydroorotate; L-Dihydroorotic acid

(S)-4,5-Dihydroorotate; (S)-Dihydroorotate; Dihydro-L-orotate; Dihydro-L-orotic acid; L-Dihydroorotate; L-Dihydroorotic acid

(S)-4,5-Dihydroorotate;(S)-Dihydroorotate;Dihydro-L-orotate;Dihydro-L-orotic acid;L-Dihydroorotate;L-Dihydroorotic acid

(S)-Dihydroorotate

(S)-dihydroorotic acid

2,6-Dioxohexahydro-4-pyrimidine carboxylic acid

2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid

4,5-Dihydroorotic acid

4,5-dihydroorotic acid; 5,6-dihydro-orotic acid; DL-dihydroortotic acid; Hydroorotic acid

4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-,(4S)-

CHEBI:417; CHEBI:42132; CHEBI:18778

Dihydroorotate

Dihydroorotic Acid

DIOXOHEXAHYDROPYRIMIDINECARBOXYLICACI

DL-Dihydroorotic acid

DNC000559

L-dihydroorotate

L-Dihydroorotic acid, 98%

L-Dihydroorotic acid, 99%

L-DIHYDROOROTICACID

L-Hydroorotic acid

MFCD00006030

MFCD00085339

NA

SS-0603

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.80 -4.04 -45.24 2 6 -1 98 157.105 1 ↓

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 1.27e+01 g/l DrugBank-experimental
Mp [°C] 254 - 255 Acros Organics
Melting_Point 254-255? dec. Alfa-Aesar
Purity 95+% Matrix Scientific
Purity 98% Fluorochem
UniProt Database Links CARB_STAAR; CARB_STAAS; CARB_STAAT; CARB_STAAW; CARB_STACT; CARB_STAEQ; CARB_STAES; CARB_STAHJ; CARB_STAS1; CARB_STRA1; CARB_STRA3; CARB_STRA5; CARB_STRAW; CARB_STRCO; CARB_STRE4; CARB_STRGC; CARB_STRGG; CARB_STRMU; CARB_STRP1; CARB_STRP2; CARB_STRP3; CAR ChEBI
Patent Database Links EP0933633 ChEBI
H phrase H315: Causes skin irritation Acros Organics
H phrase H315: Causes skin irritation; H319: Causes serious eye irritation; H335: May cause respiratory irritation Acros Organics
Warnings IRRITANT Matrix Scientific
P phrase P280: Wear protective gloves/protective clothing/eye protection/face protection Acros Organics
P phrase P280: Wear protective gloves/protective clothing/eye protection/face protection; P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing; P302+ P352: IF ON SKIN: W Acros Organics
R phrase R36/37/38: Irritating to eyes, respiratory system and skin. Acros Organics
Reactome Database Links REACT_669; REACT_744 ChEBI
S phrase S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Acros Organics
S phrase S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39: Wear suitable gloves and eye/face protection. Acros Organics
Hazard XI: Irritant Acros Organics

Activity (Go SEA)

Direct Reactome Annotations (via ChEBI)

Description Species
De novo synthesis of UMP
Pyrimidine biosynthesis

Analogs ( Draw Identity 99% 90% 80% 70% )